SIRT3 and mitochondrial disease: However, the reverse was seen in the PD and mitochondrial disease cases (effect size<0.25), showing a significant loss of response compared to the controls (ANOVA, p = 0.035, PD, p = 0.041, MITO, SIRT3; PD, p = 0.006, MITO, p = 0.008, PINK1).