LEF1 and head and neck cancer: Considering that LEF1 is associated with histone modification [30, 31] and that the KDM4 subfamily of histone-modifying enzymes is dysregulated in OSCC [18], we analysed the expression of LEF1 and KDM4s (KDM4A–D) using The Cancer Genome Atlas (TCGA) Head and Neck Cancer dataset.