Here, we hypothesized that the N1-to-N2 chemoattractant ratio, such as the Cxcl1-to-S100a8 gene ratio, could be a better biomarker to predict the survival of breast cancer patients than the single gene since the ratio can indicate whether N1 is the dominant neutrophil phenotype in the MNs. The gene discussed is S100A8; the disease is breast cancer.