Because the lungs of mice with non-metastatic breast cancer developed potent antitumor immunity, we found 4T1 tumor cells, which were attracted to the lungs responding to S100A8/A9 after they were transfused into the mice through intracardiac injection, were gradually eradicated in these dormant lungs and failed to develop into secondary tumors (Fig. 6h). Here, IGKV1D-22 is linked to breast cancer.