Because the lungs of mice with non-metastatic breast cancer developed potent antitumor immunity, we found 4T1 tumor cells, which were attracted to the lungs responding to S100A8/A9 after they were transfused into the mice through intracardiac injection, were gradually eradicated in these dormant lungs and failed to develop into secondary tumors (Fig. 6h). The gene discussed is IGKV1D-22; the disease is breast carcinoma.