SPP1 and neoplasm: Large-scale analyses of the gene expression and protein production in neutrophils derived from synthetic MNs and endogenous lungs of BALB/c mice bearing 4T1 tumor (Fig. 5b, c) identified the niche-specific gene signature for neutrophils, including a six-gene panel (Ifng, Spp1, Dcn, Cxcl1, Irg1, Ccl3) for scaffold neutrophils and another six-gene panel (Tgfb1, S100a8, S100a9, Il13, Prok2, Cdh1) for lung neutrophils (Fig. 5d).