Accordingly, CHAC1 and PTGS2 mRNA expressions (Fig. 6k, l) and lipid peroxidation marker 4HNE (Fig. 6m) in tumor tissues were all elevated by the combination therapy compared with PD-1 blockade alone, and these inductions were also reversed by liproxstatin-1 co-treatment (Fig. 6k–m). This evidence concerns the gene PTGS2 and neoplasm.