SOX2 and breast cancer: At the single-cell level, the expression of SOX2, OCT4, NANOG, ELF5 (inhibits the transcription of SNAI2 and represses EMT [28] and proliferation of breast cancer cells [29]), and ITGB1 (promotes cell motility and contributes to the EMT [30]) were significantly increased in Δ40p53 cells compared to LeGO cells (Fig. 3A).