However, unlike selective receptors such as NBR1 that mediate selective autophagy and promote the aggregation and subsequent targeting of ubiquitylated protein cargoes to ATG8-positive autophagosomes under stresses21, JAM1 is degraded by autophagy and jams mutants show increased formation of autophagosomes and higher resistance after nematode infection. This evidence concerns the gene NBR1 and Nematoda infectious disease.