IKBKB and Huntington disease: IKBKB is a pleiotropic kinase capable of signalling via diverse pathways (Hacker & Karin, 2006; Perkins, 2007; Chau et al, 2008; Israel, 2010; Schrofelbauer et al, 2012) and may therefore contribute both positively and negatively to HD pathology, depending on cellular context and intracellular signalling homeostasis.