Of the candidate tools to increase N-terminal HTT phosphorylation, IKBKB represents one of the better validated enzymes reported to be involved in regulating pS13 or pS13/pS16 levels in cellular and animal models of HD (Thompson et al, 2009; Atwal et al, 2011; Bustamante et al, 2015; Ochaba et al, 2019), including in an endogenous HTT context in mice (Ochaba et al, 2019). The gene discussed is IKBKB; the disease is Huntington disease.