Necrosis is common in human PDAC and related to poor prognosis for all stages.63 The enrichment of a CD39+ CD73+ double population, potentially able to independently produce adenosine, does not seem to correlate with IOT-resistant or responsive tumor models, but there is a difference when the target of adenosine (Adora2a receptor), is considered. This evidence concerns the gene NT5E and neoplasm.