Human PDAC tumor cells express CD73 and demonstrate weak sensitivity to the targeting of CD73 in vitro.36 48 For this reason, we sought to investigate whether murine KPCY-derived cell lines (which are associated with contrasting ability to generate IOT-resistant or responsive tumors when reimplanted in syngeneic mice) express the proteins of the canonical adenosine pathway (CD39, CD73 and Adora2a). The gene discussed is ENTPD1; the disease is neoplasm.