ITGAM and neoplasm: When we investigated the cell population distribution in the different areas using IMC in IOT-resistant tumors, we noted in the necrotic margin areas a 2.7-fold increase in the number of infiltrating CD11b+ myeloid cells (mean 1970 in the necrotic margin vs 730 in viable tumor CD11b+ cells/mm2), that led to a significant decrease of the ratio between cancer cells/myeloid cells (online supplemental figure 5A).