Genes associated with hypoxia response and vasculogenesis (eg, Hif1a, Slc2a1, Hilpda, Adm, Vegfa, Vegfd), immunity and immune suppression (eg, Cd274, Cd209, Mrc1, Cd200, Il1a, Il6, Ptgs2) and tumor stroma/extracellular matrix (ECM) organization (eg, Col5a3, Col6a3, Itga2, Mmp13, Mmp3, Mmp9, Ereg, Pthlh) were significantly downregulated by the treatment (figure 5B,C). The gene discussed is MMP13; the disease is neoplasm.