As we observed in the naturally occurring sarcopenia model of aged BL6 mice, the triceps muscle from SOD1KO mice showed resistance to sarcopenia to start with, and no treatment effect was noted in fibre size compared with untreated cohort (TableS3) although modest but not significant switch to STO in females and FTO in males was noted (Figure S5). The gene discussed is FTO; the disease is sarcopenia.