Immunoglobulin M (IgM) istypically used as a marker for the serodiagnosis of current infection, while immunoglobulin G (IgG) is used to identify recent infection.However, diagnosis is complicated by several factors; in the early stages of infection (up to 8 weeks), antibodies may be absent, whereas antibodies may persist for years after recovery from disease [10].Therefore, to have therapeutic value, the clinical presentation and background seroprevalence should be considered in interpreting serological test results[11]. The gene discussed is CD40LG; the disease is infection.