AD-Tau also could not upregulate the mRNA expression of iNOS (Supplemental Figure 4E), TNF-α (Supplemental Figure 4F), IL-1β (Supplemental Figure 4G), and CD11b (Supplemental Figure 4H) mRNAs in TLR2–/– microglia. The gene discussed is TLR2; the disease is Alzheimer disease.