The characteristic tau accumulation and formation of neurofibrillary tangles (NFTs) in multiple brain regions are well manifested in diseases including Alzheimer’s disease (AD), progressive supranuclear palsy (PSP), frontotemporal dementia (FTD), Pick’s disease, and corticobasal degeneration (CBD) (1, 2). The gene discussed is MAPT; the disease is Alzheimer disease.