As evident from double-label immunofluorescence of Iba1 and iNOS (Supplemental Figure 5D), wtTIDM, but not mTIDM, peptide strongly suppressed the level of IbaI (Supplemental Figure 5E) and iNOS (Supplemental Figure 5F) proteins in AD-Tau–stimulated WT microglia. This evidence concerns the gene NOS2 and Alzheimer disease.