The characteristic tau accumulation and formation of neurofibrillary tangles (NFTs) in multiple brain regions are well manifested in diseases including Alzheimer’s disease (AD), progressive supranuclear palsy (PSP), frontotemporal dementia (FTD), Pick’s disease, and corticobasal degeneration (CBD) (1, 2). Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.