Therefore, SH-SY5Y cells were transfected with either WT [p-MAPT(WT)] or mutated [p-MAPT(mut)] tau promoter–driven reporter constructs and then stimulated with MPP+ (parkinsonian neurotoxin), HIV-I Tat (one of the etiological agents for HIV-associated neurocognitive disorder), gp120 (HIV-1 envelope glycoprotein), TNF-α (proinflammatory cytokine), poly IC (one of the etiological reagents for viral encephalopathy), flagellin (bacterial infection), and IFN-γ (Th1-released cytokine). The gene discussed is ITIH4; the disease is bacterial infectious disease.