IFNG and neoplasm: After OV treatment, IFNγ increases in the tumor interstitial fluid in both MEERvvR and MEERvvS; however, in accordance with a more fragile phenotype, only MEERvvS infiltrating Treg cells have increased IFNγ signaling and consequent IFNγ production, consistent with previous data (Overacre-Delgoffe et al., 2017).