FLT3 and acute myeloid leukemia: FLT3-ITD mutations especially with high mutant to wildtype (mutant/wild type) allelic ratio [3] are associated with an unfavorable prognosis [4] due to a particularly high risk of AML relapse and leukemic death despite treatment with allogeneic hematopoietic stem cell transplantation (HSCT) [3, 5].