Further, the data from this study indicate that relative to CPS ≥ 20, OncoPrism-HNSCC provides superior sensitivity (0.79 vs 0.64, p = 0.005) and specificity (0.70 vs 0.61, p = 0.009) in monotherapy patients relative to PD-L1 IHC (Table 2). This evidence concerns the gene CD274 and head and neck squamous cell carcinoma.