Of note, several immune-related pathways were identified in the low-risk group, including Primary immunodeficiency, Intestinal immune network for IgA production, etc. For further investigating the relation of the DRGs model to the immune status, we appraised the difference in the level of TIICs, the activity of immune-related functions, and the response to immunotherapy between the two groups. The gene discussed is CD79A; the disease is inborn error of immunity.