SIRT1 and cardiovascular disorder: The accumulation of 4‐HNE has been detected in various cardiovascular diseases, which increases the carbonylation of proteins, including sirtuin 1 (SIRT1),[15] voltage‐dependent anion channel1 (VDAC1), mitoCa2+ uniporter (MCU),[16] and succinate dehydrogenase (SDH),[17] impairs cellular homeostasis, and promotes cardiac dysfunction.