OTUD5 and neoplasm: OTUD5 negatively regulate IFN‐I expression by downregulating TRAF3 K63‐linked polyubiquitination.[21] In addition, OTUD5 promotes DNA damage repair by inhibiting Ku80 degradation or regulating FACT‐dependent transcription at damaged chromatin.[22, 23] Meanwhile, OTUD5 can regulate tumor and immunity by hydrolyzing specific linkage types within polyubiquitin to modulate substrates stability or activity.[24, 25] However, there are few reports addressing the function of OTUD5 in cardiovascular disease.