GPX4 and cardiovascular disorder: Ferroptosis is a new type of regulated cell death driven by excessive iron‐dependent lipid peroxides.[5, 6] Accumulating evidence has shown that ferroptosis plays a key role in the pathogenesis and progression of diverse cardiovascular diseases, including MI/R.[7] Targeting ferroptosis may be a potential strategy for the management of MI/R injury.[8] Glutathione Peroxidase 4 (GPX4), which converts lipid peroxides to less harmful lipid alcohols, has emerged as a key regulator that inhibits ferroptosis.