GPX4 and cancer: It has been reported that DMOCPTL (a derivative of the natural product parthenolide) and Bufotalin (a natural small molecule) can facilitate the degradation of GPX4 and trigger ferroptosis in cancer cells.[37, 38] In addition, FINO2 (an endoperoxide‐containing 1,2‐dioxolane) and Honokiol (a biphenolic compound) can also initiate ferroptosis by inhibiting the activity of GPX4.[39, 40] Interestingly, through screening key ferroptosis‐associated molecules, we found that only GPX4 was regulated by 4‐HNE.