CSF2 and breast cancer: For example, it has been reported that the high production of C‐C motif chemokine ligand 18 (CCL18) from TAMs promotes the invasion and metastasis of breast cancer xenografts via its functional receptor PITPNM family member 3 (PITPNM3).[23] TAM‐secreted CCL18 can also form a positive feedback loop with CSF‐2 of cancer cells to induce epithelial‐to‐mesenchymal transition (EMT), cell migration, invasion, and metastasis of breast cancer cells.[24] Moreover, Liu et al.