The top-ranked DMP associated with anti-TNF treatment was cg11047325 annotated to the SOCS3 gene, involved in the negative regulation of the JAK-STAT pathway and thought to play a role in modulating the outcome of infections and autoimmune diseases41 [effect size per week 0.0008, p = 1.91 x 10-41]. Here, SOCS3 is linked to infection.