Rodent studieshave also indicated that antidepressant-like effects and their associatedmolecular and structural changes are coupled to TrkB downstream signalingpathways, most notably the activation of mTOR and its effector P70S6Kand the inhibition of GSK3β.1,3,35 In this study, we show that the phosphorylation ofTrkB, P70S6K, and GSK3β is regulated in mice by various classicalantidepressants, as well as numerous sedative-anesthetic drugs lackingany established clinical value in the treatment of depression. The gene discussed is RPS6KB1; the disease is major depressive disorder.