RAPGEF4 and cancer: Finally, EPAC was shown to play a role in various cancers (Huk et al., 2018; Kumar et al., 2018) and tumoral processes (Jansen et al., 2016; Almahariq et al., 2015; Almahariq et al., 2016), suggesting EPAC as a potential therapeutic target for cancer treatments (Kumar et al., 2018; Wang et al., 2017).