In addition, inhibition of EPAC1 was proposed as a therapeutic strategy for the treatment of cancers such as melanoma, pancreatic, or ovarian cancers (Almahariq et al., 2016; Baljinnyam et al., 2014; Baljinnyam et al., 2011; Gao et al., 2016). This evidence concerns the gene RAPGEF3 and ovarian cancer.