However, EPAC1 KO mice exhibited a preserved cardiac function after Dox treatment as evidenced by unaltered ejection fraction (EF) and left ventricle end-diastolic volume (LVEDV) (Figure 5a, b, c, f, and g) indicating a complete prevention of DCM development. The gene discussed is RAPGEF3; the disease is familial dilated cardiomyopathy.