In a study investigating the effects of curcumin on white matter damage after stroke, the use of AAV‐mediated NLRP3 knockdown was found to reduce pyroptosis‐related protein levels in the peri‐infarct area of mice 21 days after ischemia–reperfusion, alleviating the post‐stroke white matter lesions.45 Here, NLRP3 is linked to stroke disorder.