Injecting of AAV5‐GFAP‐hIGF‐1 into the cortex and striatum of middle‐aged rats 6–8 weeks prior to MCAO surgery facilitated the expression of hIGF‐1 in glial fibrillary acidic protein (GFAP) and was found to promote activation of regulatory T cells and to infiltrate M2 macrophages in the ischemic hemisphere, leading to improved neural function within 24 h after stroke.44 The gene discussed is GFAP; the disease is stroke disorder.