Thus, to explicitly examine which cell type mainly expressed ZNRF2 in HCC tissue, computing the t‐SNE plot and labelling cells based on the single‐cell data set GSE112271 that we obtained from the GEO database38 revealed an ecosystem of cells including hepatocytes (HCC) (ALB and FGG), cancer‐associated fibroblasts (CAF) (ACTA2), endothelial (KDR, VWF), myeloid‐derived (HLA‐DQB1, CD68) and sporadic B‐cells (IGJ, CD79A) (Figure 9B, C). This evidence concerns the gene ZNRF2 and cancer.