The S82 site of ZNRF2 exhibited higher phosphorylation levels in several primary tumour tissues, such as BRCA (p = 6.6e‐04), clear cell RCC (p = 2.0e‐13), HNSC (p = 2.0e‐03), GBM (p = 1.8e‐05) (Figure 5B,C,F,G), compared to normal tissues; however, the S151 site of ZNRF2 exhibited lower phosphorylation levels in several primary tumour tissues, such as BRCA (p = 6.0e‐03), PAAD (p = 4.1e‐03) and HNSC (p = 1.0e‐11) (Figure 5B,D,F). Here, ZNRF2 is linked to neoplasm.