The defective POLD1 function can induce cellular senescence and aging‐related pathologies, including the reduced lifespan of mice and the occurrence of mandibular hypoplasia, deafness, progeroid features, and lipodystrophy (MDPL), Werner syndrome, multiple tumors, and Alzheimer's disease (AD) (Lagisetty et al., 2022; Nicolas et al., 2016; Robinson et al., 2021). Here, POLD1 is linked to Alzheimer disease.