Moreover, we confirmed the effect of RJx-01 in an inducible muscle-specific OPA1-KO mouse model, which recapitulates in just 3 months all the features of sarcopenia (e.g., atrophy, weakness, reduced physical activity, fiber type switching, mitochondrial dysfunction, oxidative stress, denervation, and a sterile systemic inflammatory response). This evidence concerns the gene OPA1 and sarcopenia.