PLCG2 and irritable bowel syndrome: Among putative IBD risk genes, glial cells show high expression of ZNF831 (which participates in the HNF4A pathway), C7orf72 (which initiates the IRf5 pathway) in the inflamed colon, as well as elevated expressions of PRKCB and PLCG2 (which participate in the IRF8 pathway together), BACH2 (which participates in the TAB2 pathway to recruit TAF8), PTPRC (which participates in the IRF6 pathway), and IKZF1 (which participates in the IRF5 pathway) in both healthy and inflamed colon samples.148