We also observe neurodegenerative phenotypes when TBP is expressed specifically in fly eyes, a long-used genetic platform for understanding proteotoxic neurodegenerative diseases (Bonini 1999; Bonini and Fortini 2003; McGurk and Bonini 2012; Tsou et al. 2013; Blount et al. 2014; Burr et al. 2014; Casci and Pandey 2015; Tsou et al. 2015, 2016). Here, TBP is linked to neurodegenerative disease.