DKK2 and metastatic malignant neoplasm in the lymph nodes: DKK2 methylation (76.5% vs 45.2%, respectively, χ2 = 5.239, P = 0.022) and DKK2 mRNA expression (11.8% vs 37.1%, respectively, χ2 = 3.958, P = 0.047) are significantly different between patients with or without lymph node metastasis (Table 3).