Codelivery of DACHPt and NCTD efficiently stimulated tumor ICD to elicit tumor immunogenicity for CTL priming and infiltration and downregulated the PD‐L1 levels in tumor cells via a β‐catenin‐PD‐L1 pathway simultaneously, thus turning an immune‐suppressive tumor into a T cell‐inflamed tumor and strengthening CTL‐mediated antitumor immune responses. The gene discussed is CD274; the disease is neoplasm.