To test whether DOCK3 plays a major role in ZBED6 depletion mediated‐resistance against muscle atrophy under septic condition, we established a primary myotube culture system, which was widely used for in vitro muscle atrophy study.[25] Compared with normal controls, knockdown of ZBED6 protected sepsis‐induced myotube atrophy (Figure6A,B) and reduced the protein expression of ATROGIN‐1 (Figure 6C), accompanied with high protein levels of DOCK3 (Figure 6C). Here, DOCK3 is linked to Sepsis.