To explore the mechanism underlying ZBED6‐regulated sepsis‐induced muscle atrophy, we compared the transcriptomes of nine anatomically distinct skeletal muscle tissues throughout the body (two in the forelimb, three in the trunk, and four in the hindlimb) from septic ZBED6−/− pigs and WT controls (Figure S5A–C, Supporting Information), and identified 13 genes with significant expression changes between ZBED6−/− pigs and WT controls across nine muscles (Figure5A). This evidence concerns the gene ZBED6 and Sepsis.