To determine whether ZBED6 is implicated in sepsis‐induced muscle atrophy, we collected muscle biopsies and plasma samples from 25 sepsis patients with muscle loss (patients lost more than 10% of the cross‐sectional area (CSA) of the rectus femoris (RF‐CSA) were recruited) and 15 orthopedic controls. The gene discussed is ZBED6; the disease is Sepsis.