TLR4 and Increased total leukocyte count: Inflammation is one of the main drivers of sepsis‐induced muscle atrophy.[2, 25] Here, we found that both septic WT and ZBED6−/− pigs developed persistent fever (Figure S4A, Supporting Information), leukocytosis, and neutrophilia (Figure S4B,C, Supporting Information), as well as similar mRNA levels of inflammatory marker genes IL‐6, TNF‐a, NLRP3, and TLR4 in skeletal muscle (Figure S4D–F, Supporting Information).