Since its identification in 2009 as a transcription factor, ZBED6 has been reported to regulate the growth of skeletal muscle in placental mammals under physiological conditions.[13] In mice and pigs, deficiency of ZBED6 increased growth rate and skeletal muscle mass.[13, 14] Our finding that ZBED6 regulates sepsis‐induced muscle atrophy extends its role from physiological conditions to a type of muscle pathology, expanding the function and potential application of ZBED6. This evidence concerns the gene ZBED6 and Sepsis.