To further determine the role of ZBED6 in sepsis‐induced muscle atrophy, we generated septic ZBED6‐deficient pigs (ZBED6−/−) based on our previous ZBED6−/− pigs.[14a] Two weeks after surgery, sepsis caused smaller weight reductions of carcass (CW, 7.05% vs 13.60%), carcass fat (2.96% vs 3.20%), and carcass lean meat (CLW, 3.08% vs 8.71%) (Figure2A) in ZBED6−/− pigs than in WT pigs when compared to their respective controls. This evidence concerns the gene ZBED6 and Sepsis.