ZBED6 and Sepsis: To test whether DOCK3 plays a major role in ZBED6 depletion mediated‐resistance against muscle atrophy under septic condition, we established a primary myotube culture system, which was widely used for in vitro muscle atrophy study.[25] Compared with normal controls, knockdown of ZBED6 protected sepsis‐induced myotube atrophy (Figure6A,B) and reduced the protein expression of ATROGIN‐1 (Figure 6C), accompanied with high protein levels of DOCK3 (Figure 6C).