TNF and post-traumatic stress disorder: Interestingly, co-expression network analyses indicate that while immune-related networks enriched for microglia-specific transcripts are indeed downregulated in the ventromedial PFC, other immune-related networks (e.g., enriched for TNF and interleukin genes) are largely upregulated in the dlPFC [190], suggesting subregional specificity of neuroimmune suppression in PTSD.