It has been proposed that deficits in context‐free memory, which includes semantic memory, may actually represent one of the earliest clinical markers of AD (Didic et al., 2011), based on the fact that in the early transentorhinal stage of the disease, neurofibrillary tangles related to tau pathology are mainly present in the subhippocampal region (perirhinal and entorhinal cortices). The gene discussed is MAPT; the disease is Alzheimer disease.