Lastly, while we did find a significant correlation between VEGFA plasma concentration and BBB leakage rate in NAWM, the low R2 means that a considerable amount of the variance in BBB leakage is explained by other factors which we did not account for, such as increased pulsatility and impaired glymphatic drainage as a consequence of hypertension [35, 43, 48]. Here, VEGFA is linked to Hypertension.