INSR and polycystic ovary syndrome: Despite the fact that candidate gene association studies and genome-wide association studies have identified several susceptibility genes and single-nucleotide polymorphism loci significantly associated with PCOS, such as follicle stimulating hormone receptor gene (FSHR, rs2268361, rs2349415), insulin receptor (INSR, rs2059807), it is still difficult to explain the complexity of PCOS etiology and clinical manifestations [9–11].