Having established that the TGFβ/SMAD pathway inhibitor LY compromises GATA2-induced PCa cell growth and invasiveness (Fig. 5a-c), together with a previous study showing that GATA2 inhibitor K7174 blocks the recruitment of GATA2 to transcriptional target genes [22], we sought to examine whether GATA2 and SMAD4-regulated eQTL genes can be potential therapeutic targets for PCa. This evidence concerns the gene TGFB1 and posterior cortical atrophy.