SMAD4 and posterior cortical atrophy: We then extracted enriched risk SNPs and integrated multi-sources of eQTL data to define a detailed locus-SNP-eGenes association Circos map (Fig. 8b), pinpointing a potential functional association among GATA2, SMAD4 and the PCa susceptibility locus at 6q22 harboring the GWAS-reported variant rs339331 that was mechanistically investigated in our previous study [40].