To assess if these findings hold clinical impacts, we further performed correlations of these pathways with the expression of GATA2 or SMAD4 in several independent cohorts of PCa patient tumors, and found that GATA2 or SMAD4 expression levels were significantly and positively correlated with EMT scores (Fig. 4k and Fig. S4n) and TGFβ singaling scores (Fig. 4l and Fig. S4o), respectively. Here, SMAD4 is linked to posterior cortical atrophy.