As shown in Fig. 5m, TGFβ1 further enhanced GATA2- and SMAD4-directed reporter activity but showed little influence on the GATA2 activation to SBE4, suggesting that GATA2 interacts and synergize with SMAD4 to promote the TGFβ1 signaling in PCa. Here, TGFB1 is linked to posterior cortical atrophy.