SMAD4 and posterior cortical atrophy: The RNA-seq revealed that 2,109 and 2,362, or 1,186 and 1,054 genes were significantly up- and downregulated, respectively, upon GATA2 or SMAD4 knockdown in 1F5 cells (Fig. S4k, l), suggesting that GATA2 and SMAD4 profoundly influence gene expression programs in PCa.