To further consolidate these findings, we carried out additional enrichment analysis in a large collection of annotated gene sets, the results coherently revealed the strong enrichment of genes downregulated upon GATA2 or SMAD4 knockdown for pathways relevant with cell proliferation (Fig. S4m), cancer metastasis and TGFβ signaling (Fig. 4j). This evidence concerns the gene SMAD4 and cancer.