To further consolidate these findings, we carried out additional enrichment analysis in a large collection of annotated gene sets, the results coherently revealed the strong enrichment of genes downregulated upon GATA2 or SMAD4 knockdown for pathways relevant with cell proliferation (Fig. S4m), cancer metastasis and TGFβ signaling (Fig. 4j). The gene discussed is GATA2; the disease is cancer.