The result showed that SMAD4, as the only transcription factor among the 10 proteins identifed as potential GATA2 interactors, was fundamentally top-ranked as an essential gene for PCa cell survival (Fig. S4a), indicating that the potential interaction between GATA2 and SMAD4 is likely to be functionally important for PCa cell growth and tumor progression. Here, SMAD4 is linked to neoplasm.