We thus performed an integrated analysis of RNA-seq transcriptome profilings upon GATA2 or SMAD4 knockdown and their genome-wide chromatin occupancy data in 1F5 PCa cells (Fig. S4k, l), thereby resulting in 41 direct target genes of GATA2 and SMAD4 (Fig. 7e, upper panel). The gene discussed is SMAD4; the disease is posterior cortical atrophy.