We next found a similar synergistic effect of K7174 and LY on other eQTL genes, including TMPRSS2, SIX-6, ATP2B1-AS1, TLE4, HOTTIP and MBNL1 (Fig. S9n, o), suggesting a potential clinical application with the identified eQTL genes, their upstream signaling pathways and transcription factors in PCa. The gene discussed is SIX6; the disease is posterior cortical atrophy.