Given that GATA2 and SMAD4 share many commonly regulated pathway categories implicated in PCa progression, we next explored the clinical significance of their association with AR signaling status and observed that the joint expression levels of GATA2 and SMAD4 strikingly correlated with AR signaling scores across multiple independent clinical PCa datasets (Fig. 7d and Fig. S7a, b). Here, GATA2 is linked to posterior cortical atrophy.