In light of the robust clinical correlation between GATA2 upregulation and PCa metastasis as described above (Fig. 1e, h, j-m, p and Fig. S1g), we next experimentally substantiated the role of GATA2 in metastasis and inoculated RWPE2-GATA2 cells or PC3-GATA2 cells into SCID male mice via the tail vein injection or left ventricle injection. This evidence concerns the gene GATA2 and posterior cortical atrophy.