SMAD4 and Familial prostate cancer: Consistent with previous studies showing that downregulation of GATA2 inhibits PCa LNCaP cell proliferation and migration [71] and attenuates tumorigenicity in castration resistant prostate cancer [95], our data further showed that GATA2 overexpression potentiate PCa cell proliferation and metastasis both in vitro and in vivo, mechanistically, this is likely due to physical interaction between GATA2 and SMAD4 for genome-wide chromatin co-occupancy and co-regulation of PCa genes and metastasis pathways, including TGFβ and AR pathways.