We subsequently incorporated GWAS identified PCa risk single nucleotide polymorphism (SNP) loci and retrieved their proxy SNPs in tight linkage disequilibrium (LD, R2 ≥ 0.5), and computed the enrichment of these SNP-containing regions in the GATA2 or SMAD4 ChIP-seq peaks across multiple PCa cell lines (see Materials and Methods). Here, GATA2 is linked to posterior cortical atrophy.