We next integrated a set of genome-wide CRISPR/Cas9-mediated loss-of-function screen data in the PCa cell line LNCaP [14] and observed that GATA2, coding a known transcription factor is top-ranked among all other copy number amplified potential causal genes, displaying strongest essentiality for PCa cell survival (Fig. 1a, Fig. S1c and Table S9). Here, GATA2 is linked to posterior cortical atrophy.