Notably, we found that for patient group with Gleason score 7, compared to individuals having tumors expressing higher level of RFX6 or GATA2, patients with PCa tumors expressing both higher levels of RFX6 and GATA2 were at significantly higher risks of biochemical relapse and metastasis (Fig. S9h-m). This evidence concerns the gene GATA2 and posterior cortical atrophy.