The best characterized function of GATA2 is to exert as a pioneer transcription factor, by binding to the DNA regions of closed chromatin, initiating hierarchical recruitment and occupancy of other regulatory proteins like FOXA1 and AR to regulate genes in promoting prostate tumor growth and metastasis via AR-dependent or AR-independent network cascades [17–22]. The gene discussed is GATA2; the disease is prostate neoplasm.