Consistent with this hypothesis, recent studies have illustrated that combination of GATA2 inhibitor K7174 and AR antagonist enzalutamide suppress the proliferation of PCa cells [22] and combination of TGFβ signaling inhibitor LY2157299 and AR antagonist enzalutamide alleviate the proliferation and metastasis of PCa both in vitro and in vivo [101, 102], respectively. Here, TGFB1 is linked to posterior cortical atrophy.