As shown in Fig. 3a-c, cells with siRNAs or shRNAs against GATA2 significantly attenuated cell proliferation when comparing to the cells transfected with control siRNA or shRNA, consistent with genome-wide CRISPR/Cas9-screening data [14] showing GATA2 as the most essential gene for PCa cell survival (Fig. 1a) and previous report, indicating that depletion of GATA2 reduced cell proliferation and migration of LNCaP cells [71]. Here, GATA2 is linked to posterior cortical atrophy.