The RNA-seq revealed that 2,109 and 2,362, or 1,186 and 1,054 genes were significantly up- and downregulated, respectively, upon GATA2 or SMAD4 knockdown in 1F5 cells (Fig. S4k, l), suggesting that GATA2 and SMAD4 profoundly influence gene expression programs in PCa. The gene discussed is GATA2; the disease is posterior cortical atrophy.