KLK3 and cancer: In this study, we found that GATA2 is top-ranking among the highly amplified genes in cancer genomes of PCa patients and indicates as the most essential gene for PCa cell survival, showing positive correlations with its elevated expression in tumors of PCa patient mostly accompanied with higher Gleason score, advanced tumor stage, elevated PSA levels and shorter biochemical recurrence-free survival time, consistent with previous studies also showed that GATA2 is upregualted in PCa and its upregulationcorrelates with poor prognosis of PCa patients [20, 62, 63, 95].