Autoantibody results were available in 55.0% (8758) of individuals without an autoimmune disease and positive ANA; and in 5.3% (461) a positive for at least one of these autoantibodies: anti-dsDNA 1.1%, (77 of 6809 tested), anti-Sm 0.4% (31 of 7440 tested), anti-RNP 1.1% (84 of 7334 tested), anti-Ro/SSA 1.8% (139 of 7940 tested), anti-La/SSB 1.8% (136 of 7769 tested), anti-Scl70 1.2% (85 of 7310 tested), and anti-Jo1 0.8% (1 of 121 tested). This evidence concerns the gene TRIM21 and autoimmune disease.