Additional autoantibody results were reported in 72.6% (7,937) of patients with autoimmune disease and a positive ANA, and 20.4% (1622) a positive test for at least one of these autoantibodies: anti-dsDNA 9.8% (641 of 6527 tested), anti-Sm 2.1% (146 of 6843 tested), anti-RNP 5.1% (337 of 6667 tested), anti-Ro/SSA 8.7% (613 of 7021 tested), anti-La/SSB 6.2% (422 of 6815 tested), anti-Scl70 2.1% (143 of 6678 tested), and anti-Jo1 8.1% (13 of 160 tested). The gene discussed is TRIM21; the disease is autoimmune disease.