BTG3 and autoimmune disease: While ANAs are important biomarkers used in the diagnosis of several autoimmune diseases, the International Consensus on Antinuclear Antibody (ANA) Patterns (ICAP) has acknowledged that the term encompass antibodies directed at various cellular components and has proposed to a change in terminology to encompass 15 nuclear, 9 cytoplasmic, and 5 mitotic Hep-2 IIFA patterns [19].