IL6 and COVID-19: Monoclonal antibodies (e.g. tixagevimab + cilgavimab), direct-acting antiviral agents (e.g. remdesivir), corticosteroids (e.g. dexamethasone), interleukin-6 antagonists (e.g. tocilizumab) and Janus kinase inhibitors (e.g., baricitinib) have been evaluated in guidelines for the treatment of patients with COVID-19 after RCT results became available indicating their benefit in specific populations [50, 51].