Here, it should be emphasized that (i) these five patients represent the totality of patients carrying a heterozygous LPL c.862G > A variant among our 492 HTG-AP patients analyzed from January 2020 to December 2022 and (ii) LPL c.862G > A was the only variant we found in these five patients, in terms of rare nonsense, frameshift, missense or canonical GT-AG splice site variants in the five primary HTG-related genes analyzed (i.e., LPL, LMF1, GPIHBP1, APOA5 and APOC2). The gene discussed is GPIHBP1; the disease is alkaline phosphatase measurement.