Among them, various miRNAs are known to modulate the expression of α-synuclein (miR-7, miR-153 and miR-203a-3p) and further PD-causing genes such as Parkin (miR-103a-3p, miR-146a, miR-181a and miR-218), LRRK2 (miR-205 and miR-599), DJ-1 (miR-494 and miR-4639) or PTEN-induced kinase 1 (PINK1) (miR-27a/b). The gene discussed is PRKN; the disease is Parkinson disease.