TLR4 and Cerebral ischemia: Intracerebral overexpression of miR-155 further enhanced the expression of pro-inflammatory cytokines in the ischemic brain by upregulating TLR4 and NF-κB expression as well as downregulating SOCS1 and MyD88, whereas miR-155 knockout abrogated the effects of cerebral ischemia on the TLR4/NF-κB/MyD88/SOCS1 axis [405].