CircSLC8A1, upregulated in the substantia nigra of PD individuals probably due to oxidative stress, regulates the activity of miR-128, indirectly leading to the deregulation of PD-associated miR-128 targets such as the neurodegeneration and aging-related B lymphoma Mo-MLV insertion region 1 homolog (BMI1), Sirt1, or axis inhibition protein 1 (AXIN1) transcripts [88, 145]. Here, AXIN1 is linked to Parkinson disease.