In murine ischemic stroke, the degradation of NETs by systemic application of DNase1 reduced BBB breakdown and increased neovascularization and vascular remodeling after stroke to a similar extent as compared to neutrophil depletion by injection of anti-Ly6G antibody or blockade of PAD4, an enzyme essential for NET formation, respectively [184]. This evidence concerns the gene PADI4 and stroke disorder.