CAMKK2 and myeloid sarcoma: Moreover, circ_0000518 was shown to be upregulated in CSF and in the peripheral blood of MS patients as well as to exacerbate EAE by promoting macrophage/microglial M1 polarization through the fused in sarcoma (FUS)/calcium/calmodulin-dependent protein kinase kinase beta (CaMKKβ)/AMP-activated kinase (AMPK) pathway [173].