The knockdown of MALAT1 in EAE mice exacerbated autoimmune neuroinflammation through changing the pattern of macrophage differentiation towards a M1-like phenotype as well as enhancing T cell differentiation towards pathogenic Th1 and Th17 cells, while impeding the differentiation of protective Treg cells, collectively pointing to a potential anti-inflammatory effect for MALAT1 in the context of MS [258]. The gene discussed is MALAT1; the disease is myeloid sarcoma.