LRRK2 and Parkinson disease: As an example for anti-inflammatory miRNA in the context of PD, miR-335 has been shown to be downregulated in LPS-treated or LRRK2-overexpressing microglia, in the MPTP-induced PD mouse model as well as in sera from patients with idiopathic PD and those harboring mutations in LRRK2 [288].