PRKN and Parkinson disease: In accordance with the murine model, patients with biallelic or heterozygous PARK2/PINK1 mutations exhibited elevated serum levels of mexDNA and IL-6 as compared to either healthy control subjects or idiopathic PD patients, indicating that mexDNA levels provide a good predictive potential to discriminate between idiopathic PD and PD linked to heterozygous PARK2/PINK1 mutations [29].