In samples from ET patients with JAK2 mutations, we focused on the analysis of 13 genes (ARG1, CAST, CD177, CLEC5A, DAPP1, EPS15, IGHM, IL18RAP, OLFM4, OLR1, RIOK3, SELP, and THBS1). The gene discussed is IL18RAP; the disease is essential thrombocythemia.