Correspondingly, we observe colocalization of a known trans pQTL for TSHB (rs7695810; MAF = 0.181; beta = − 0.105; SE = 0.012; P = 3.89 × 10–18) with signals for self-reported hypothyroidism (PP4 = 92.6%) and treatment for hypothyroidism (91%) [38]. The gene discussed is TSHB; the disease is hypothyroidism.