Recently, many researchers have successfully revealed the important biological process of OSBPL3 in some cancers, such as gastric cancer [12], pancreatic ductal adenocarcinoma [27], breast cancer [28], etc. To our knowledge, the correlation between the expression of OSBPL3 and the prognosis of CRC has not yet been verified. The gene discussed is OSBPL3; the disease is colorectal carcinoma.