OSBPL3 was differentially expressed in 13 tumors (bladder cancer (BLCA), cervical cancer (CESC), colon adenocarcinoma (COAD), esophageal carcinoma (ESCA), head and neck squamous cell carcinoma (HNSC), kidney renal clear cell carcinoma (KIRC), liver hepatocellular carcinoma (LIHC), lung adenocarcinoma (LUAD), lung squamous cell carcinoma (LUSC), pancreatic adenocarcinoma (PAAD), rectum adenocarcinoma (READ), stomach adenocarcinoma (STAD), and thyroid carcinoma (THCA) with P < 0.01 (Fig. 1A), and most of them in tumor tissues were up-regulated. This evidence concerns the gene OSBPL3 and head and neck squamous cell carcinoma.