In fact, biomarkers of CRC such as INHBB, SMOC2, BDNF and TBRG4 were deregulated by methylation, and leading to the metastasis and poor prognosis of CRC [36], it indicated OSBPL3 might influence the prognosis of patients by regulating the methylation process in CRC. The gene discussed is OSBPL3; the disease is colorectal carcinoma.