CST3 and Diffuse mesangial sclerosis: As expected, the differences between obese and lean BTBR mice were substantial with regard to most measured parameters; the obese mice had more epididymal white adipose tissue, larger glomerular sizes, mesangial sclerosis, more evolved albuminuria, and higher urinary concentrations (relative to creatinine) of cystatin C, carbamide, uric acid and glucose than the lean mice in this study.