Resembling MPN mice, sinusoidal vasodilation was observed in mice engrafted with PV hHSPCs (Fig. 3d,e), whereas the bone (OPN+) area was 25-fold higher in mice engrafted with ET hHSPCs, compared with PV hHSPCs (Fig. 3f,g). This evidence concerns the gene SPP1 and myeloproliferative disorder.