In conclusion, Skp2 plays a role in coupling the destruction and activity of Myc through proteasomes, and Skp2-mediated activation of Myc appears to be an important process in controlling mammalian cell growth.We found that the oncogenic role of CNOT2 is supported by available bioinformatics databases: CNOT2 was overexpressed in tumor tissues than in normal tissues in patients with PC, and high expression rates of CNOT2 correlated with lower survival rates in patients with cancer. The gene discussed is CNOT2; the disease is pachyonychia congenita.