SKP2 and pachyonychia congenita: In conclusion, Skp2 plays a role in coupling the destruction and activity of Myc through proteasomes, and Skp2-mediated activation of Myc appears to be an important process in controlling mammalian cell growth.We found that the oncogenic role of CNOT2 is supported by available bioinformatics databases: CNOT2 was overexpressed in tumor tissues than in normal tissues in patients with PC, and high expression rates of CNOT2 correlated with lower survival rates in patients with cancer.