A second category could be identified after matrisome changes that was characterized by an increase in the 14-3-3 family of proteins YWHAZ (1433Z), YWHAB (1433B) and YWHAG (1433G) associated with synaptic and neuronal coexpression, as well as multiple proteins associated with intermediary glycolytic metabolism including pyruvate kinase, l-lactate dehydrogenase B chain, fructose-bisphosphate aldolase A and phosphoglycerate mutase 1 that mapped to a diverse set of AD brain coexpression modules. The gene discussed is PGAM1; the disease is Alzheimer disease.