GO analysis indicated that DE-FRGs were enriched mainly in programmed cell death, immune system process, apoptotic process and regulation of cell death (Fig. 4A); whereas KEGG pathway analysis indicated DE-FRGs were significantly enriched in HIF-1 signaling pathway, IL-17 signaling pathway, Ferroptosis and IBD (Fig. 4B). This evidence concerns the gene IL17A and inflammatory bowel disease.