APC and lung adenocarcinoma: In lung adenocarcinoma, we found two gene sets; the first set includes six genes (TP53, EGFR, KRAS, KEAP1, STK11, and NF1) that exhibit a co-occurring mutation pattern, and the second set of four genes (SMARCA4, ATM, RBM10, and APC) (Fig. 6c), exhibit an exclusive mutation pattern.