PTEN and colorectal adenocarcinoma: Additionally, we identified specific cancer types in which certain gene pairs exhibit a significantly co-occurring mutation pattern, such as TP53 and ATRX in brain lower-grade glioma (p = 8.2 × 10–59), TP53 and PTEN in uterine corpus endometrial carcinoma (p = 9.0 × 10–29), FGFR1OP and MAP3K1 in colorectal adenocarcinoma (p = 2.7 × 10–38) and uterine corpus endometrial carcinoma (p = 2.9 × 10–05).