VHL and acute myeloid leukemia: We then calculated the somatic mutation frequencies in the 727 genes across the samples of the 41 cancer types (Supplementary Data 1) and found that the mutation frequency for different cancer genes ranged from 0% for the VHL (and other genes) in acute myeloid leukaemia to 94% for the TP53 gene in small cell lung carcinomas (Fig. 1b,c).