RUNX1 and acute myeloid leukemia: Similarly, in acute myeloid leukaemia, we found two gene sets; the first set includes six genes (FLT3, DNMT3A, NPM1, IDH3, RUNX1, and IDH1) that exhibit a co-occurring mutation pattern, and the second set of four genes (TET2, TP53, NRAS, and WT1), exhibit an exclusive mutation pattern (Fig. 6b).