Other cancer genes with high mutation frequencies include KRAS (mutated in 84%) of pancreatic adenocarcinomas and PTEN (67%) of uterine corpus endometrial carcinomas, and JAK2 (75%) of myeloproliferative neoplasms (Fig. 1c, also see Supplementary Data 1). This evidence concerns the gene PTEN and pancreatic adenocarcinoma.