CD79A and COVID-19: Although NAbs assessed in serum might underestimate the role of mucosal IgA with the potential to neutralize virus locally26, the association of improved outcomes in individuals with a more mature antibody response, and key symptom resolution and improved outcomes with IgG antibodies provided with administration of CAS + IMD, demonstrate the critical role of IgG in the resolution of severe COVID-19 illness22,32.