Moreover, MiT/TFE proteins [including melanocyte inducing transcription factor (MITF), transcription factor binding to IGHM enhancer 3 (TFE3), and transcription factor EB (TFEB)] [86], the master molecules of metabolic reprogramming, enable lysosome-autophagy system-dependent activation to buffer amino acid levels in cancer cells under conditions of starvation, thereby promoting PDAC growth [29]. Here, TFEB is linked to cancer.