Solute carrier family 39 member 4 (ZIP4) activates integrin α3 (ITGA3) by regulating the co-activation of ZEB1 and yes-associated protein 1 (YAP1) to promote EMT, tumor colonisation and organogenesis in vitro and vivo models of PC [75]. This evidence concerns the gene SLC39A4 and pachyonychia congenita.