SAMHD1 and infection: Approaches to induce proteasomal degradation of SAMHD1 using Vpx or shRNA-mediated down-regulating of SAMHD1 to improve transduction efficiency have been described; however, these techniques are not suitable for the development of clinical-grade DC therapies since they increase the risk for cell infection with viruses and induce a cytotoxic T-cell response66,67.